Cas team: cordyceps militaris can synthesis with anticancer activity of drugs he butyl spray division

on October 19th, the journal Cell ZiKan the Cell Chemical Biology, published online by Chinese academy of sciences, Shanghai institute of plant physiology ecological cheng-shu wang team’s latest research results: & other; Fungal cordycepin biosynthesis is coupled with the production of the safeguard molecule pentostatin (cordycepin with molecular biosynthesis, spray division he ding) & throughout; . DetailPic

gene cluster and synthesis of Cordycepin in cordyceps militaris, Cordycepin, COR) and spray, he Pentostatin PTN), which can inhibit the Cordycepin degradation of 3 ‘- deoxidization inosine (3’ – deoxyinosine, 3 ‘- dI)

is the first study found that the cordyceps militaris can synthesis with anticancer activity of drug injection he ding, and by the same gene cluster common synthetic Cordycepin and he butyl spray division.

he butyl spray company (pentostatin) as early as 1974 identified in bacteria, is adenosine deaminase inhibitor agents, in 1991 the FDA approval, become resistant to hairy cell leukemia (hairy cell leukemia) commercial drugs (Nipent).

cordycepin and spray division, he d have antitumor activity

in nature can generalized cordyceps sinensis infection insecticidal 1000 kinds of these fungi in insect populations of natural regulation plays an important role.

with cordyceps sinensis, cordyceps militaris and cordyceps sinensis infection such as cicada insects after the formation of the bacteria worm complex & ndash; Has a long history of medicinal cordyceps, anti-cancer, improve immunity, antibacterial and fatigue resistance and so on the many kinds of biological activity, but the active ingredient is not clear.

adenosine is cordycepin content (cordycepin) as early as 1950 in cordyceps militaris appraisal, has antibacterial, insect-resistant and antitumor biological activity, such as synthetic mechanism is unknown, but argued in academic circle and corporate world, think Chinese caterpillar fungus and so on different cordyceps sinensis has the ability of synthesis of cordycepin.

he butyl spray company (pentostatin) as early as 1974 identified in bacteria, is adenosine deaminase inhibitor agents, in 1991 the FDA approval, become resistant to hairy cell leukemia (hairy cell leukemia) commercial drugs (Nipent).

the study complete resolution of cordycepin in Cordyceps militaris, Cordyceps militaris) the biosynthesis mechanism, the other for the first time found that Cordyceps militaris could synthetic anticancer drugs & ndash; Spray he ding, the compounds are used to protect the structure stability of the synthesis of cordycepin.

cheng-shu wang research group at the completion of cordyceps militaris Genome research (Genome Biology, 2011), on the basis of through biological information analysis and gene function research, fully analyses the molecular mechanism of cordycepin biosynthesis.

their research also found that for the first time cordyceps militaris can synthesis with anticancer activity of spray he ding, and by the same gene cluster common synthetic cordycepin and he butyl spray division.

in humans, unfavorable also consuming too much cordycepin

these two adenosine molecules like play on the function & other; Protector & ndash; Be protectors & throughout; Role, that is to say, cordycepin was synthesized at the same time, the cordyceps militaris will synthesize a protect the stability of molecules.

the study also found that only in cordyceps militaris silkworm chrysalis on growth rather than a liquid fermentation, synthesis of high levels of cordycepin. But cordycepin content too high can cause cytotoxicity, fungi can start detoxification mechanisms, thereby the cordycepin deamination generated 3 ‘- deoxidization inosine (3’ – deoxyinosine). Suggests that in humans, cordycepin also shoulds not be too. In the cordycepin synthesis genes, on the basis of combination of chromatographic analysis, their research prove that Chinese caterpillar fungus and cicada, and other types of synthetic cordycepin and cordyceps sinensis can’t he butyl spray division. Using synthetic gene, heterologous expression can achieve cordycepin synthesized from yeast; By high endogenous gene expression, can be in cordyceps militaris high level synthesis of cordycepin and spray he ding, for this two kinds of active ingredients of efficient use of laid a solid technical foundation.

according to introducing, the significance of the results of the study include: (1) provides a molecular evidence of cordyceps militaris antitumor activity; 2. From the level of gene and compound proves that Chinese caterpillar fungus and cicada and other synthetic cordycepin, cordyceps sinensis can’t can’t synthesis of butyl spray division him; 3. To the quality standards of cordyceps militaris provided new molecular target & ndash; Injection department he ding; 4. For high level synthesis of cordycepin through synthetic biology technology and spray division, he provides the genetic resources.

the study by the graduate Xia Yongliang and feifei as general author completed, such as the work obtained the key project of foundation and the strategy of the Chinese academy of sciences pilot B project funding. & have spent & have spent & have spent

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