Nobel laureates Mr Bates: bacterial mutation may be faster than the development of new antibiotics

on October 16, Thomas & bull; Mr Bates (Thomas explosion do topic report.

a symphony, a dance, pop songs, these can be as music to parse the ribosome animation. On the afternoon of October 16 Shanghai science hall, the Nobel Prize in chemistry 2009 winners, a 77 – year – old American biochemist Thomas & bull; Mr Bates (Thomas explosion in theme report is done.

and the music lively, but the theme of the report with some historical sense of mission: explaining the next generation of antibiotics. Nearly 100 years ago, the accidental discovery of the antibiotics have saved millions of lives. But & other; The cunning & throughout; Bacteria can according to antibiotics, evolved resistance, resistance to antibiotics and other Power & throughout; . As the abuse of antibiotics, the problem of the bacterial drug resistance is more and more serious, human existing antibiotics face & other; Lack of parry & throughout; The risk.

in 2016, the world health organization is a quote from authoritative expert Jim & bull; O ‘neill wrote “global antibiotic resistance review pointed out that by 2050 antibiotic resistance will cause 10 million deaths each year, causing economic losses of $100 trillion.

it was reported that on October 17, Mr Bates of fudan university professor emeritus, will guide to the ribosome crystals study, research and development of a new generation of antibiotics.

the speed of the bacteria and antibiotics battle

the discovery of antibiotics started in accident & ndash; & ndash; In 1929, the British bacteriologist Alexander Fleming bacteria in the culture dish, found a strange phenomenon: a penicillium fall from the air accident in medium, it grow colonies around no bacterial growth.

because of the presence of the antibiotic, had been sentenced to death to cure bacterial infections diseases. & other; On policy makers. Throughout the &; Bacteria have evolved, the variation of antibiotic resistance in pairs & other Higher-order version & throughout; Bacteria, only more antibiotics to its & other; Uniform throughout the &; . To some extent, this be bacteria between variation and antibiotic development & other; Speed war & throughout; , resistant to multiple antibiotics & other; Super bacteria & throughout; Around the world have been reported.

Mr Bates believes that although the bacteria have your ways to break through the barrier of human, but if not use human error, antibiotic drugs instinct last longer.

& other; The speed of the resistant bacteria itself not soon, is the main reason of antibiotics abuse. Throughout the &; Mr Bates of surging news ( said.

& other; People want to improve cognition. Throughout the &; Dean at the fudan university school of medicine, the Chinese academy of sciences, Shanghai, a researcher at a drug ming-wei wang, said many people relying too much on antibiotics, but not complete finish taking treatment, which can result in residual bacteria spread to the environment, the resistance.

& other; Many of the abuse of antibiotics is not suit the remedy to the case. Some common cold is caused by a virus, antibiotics do not have any effect, antibiotics only effective against bacteria. You have to determine whether the bacteria. Throughout the &; Mr Bates said.

where is the next generation of antibiotics

he who studied the decades of ribosomes, because in ribosomal subunit crystal structure determination and analysis on the process of contribution, he won the Nobel Prize in chemistry. The ribosome is intracellular protein production factory, in the process of RNA is translated into protein plays an important role, performs according to the instructions of mRNA mission to synthesize amino acid protein polypeptide chain.

which can be regarded as a drug-resistant bacteria & other “Ming & throughout; Available for human use, one of, become against drug-resistant bacteria & other; The assassin’s mace & throughout; . At present, a lot of antibiotics is by blocking the function of the bacterial ribosome to cure various diseases caused by bacteria.

& other; Basic research on the structure and function of the ribosome is very important, it helps to find new, effective for all drug-resistant strains of antibiotics. Throughout the &; Mr Bates said.

he said that the traditional antibiotic development, it’s usually done on the basis of the old antibiotics, join different groups, or the passage of a massive small molecule drug screening. At present, as people to the antibiotic drug targets, function, structure, have more detailed understanding, artificial precise design and synthesis of antibiotics is possible.

such as Mr Bates had participate in creating Melinta Therapeutics (formerly known as Rib – X), is developing a new antibiotic RX – m1, according to the structure information of existing antibiotics, combined two kinds of antibiotics, generate the third kind of antibiotics, a 1 + 1 & gt; The effect of the two.

who is going to develop new antibiotics

& other; To be honest, I think, the speed of bacteria resistant to antibiotics, is likely to be faster than the speed of new antibiotic development. Throughout the &; Mr Bates on surging news said: & other; For pharmaceutical companies, for the sake of economic interests are no longer interested in the development of new antibiotics. Throughout the &;

the profit-driven capital makes development of antibiotics a is not cost-effective to buy and sell. Under the condition of fair use, only need to use antibiotics for a period of time, rather than heart disease, diabetes and so on need for lifetime of drugs, antibiotics, profit is not high. In such cases, the pharmaceutical enterprises large sums of money, it is difficult to spontaneous development of new antibiotics, large-scale clinical trials.

if companies don’t want to develop new antibiotics, who to do it? In Mr Bates’s view, in the end, is still done by pharmaceutical companies.

& other; If only for a pharmaceutical company to develop a new antibiotics, it also can solve some problems. Since this is a process of balance, the WHO urged, companies will realise that this is a necessary thing, and not necessarily no profits. Throughout the &; Mr Bates said.

in February 2017, the world health organization (who) has released a list of 12 kinds of the listing of antibiotic-resistant strains of bacteria, & on the other; List & throughout; Bacteria is considered by the world health organization (who) are in urgent need of the development of new antibiotics, to remind researchers and pharmaceutical companies, what they should do is priority.

in July, the G20 summit held in Germany, the G20 decided unanimously, to carry out the global antibiotic resistance research project. German federal actuarial-oriented) announced that 500 million euros to support the 10-year study.

& other; China needs to be orderly research, but open any new antibiotics should be strictly controlled. Throughout the &; Ming-wei wang said.

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